![]() ![]() ![]() Smokers tend to get a type of NSCLC called squamous cell (which accounts for more than half of lung cancers diagnosed in smokers). Named initially for how the cancer cells look under the microscope, these two types account for most of the 230,000 newly diagnosed cases of lung cancer in the U.S. Primary lung cancer refers to cancer that starts in the lungs, of which there are two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). It can start in one area of the body (in this case, the lungs) and spread (or metastasize) to other organs or the bones. Like all cancers, lung cancer begins at the cellular level and is the result of abnormal cells that reproduce rapidly and out of control. While smoking cigarettes is by far the most common cause of lung cancer, risk factors also include a family history of lung cancer and certain environmental contributors. Lung cancer, one of the most common cancers in the world, is a leading cause of cancer-related death in men and women in the United States. At Yale, we have a very active research program aimed at targeting those cancer cells that contain the mutation.” “The good news is that the types of lung cancer that nonsmokers tend to get are usually driven by a molecular change or mutation that can be detected in the tumor, and there are drugs and therapeutics available for them. “We used to think all lung cancers were the same, but now we understand that there are different kinds,” says Anne Chiang, MD, PhD, a Yale Medicine thoracic medical oncologist, and chief network officer and deputy chief medical officer for the Smilow Cancer Hospital and its Care Centers. In the past five to 10 years, new knowledge about lung cancer has changed the way it is treated in both smokers and nonsmokers. Smokers and non/never-smokers tend to develop different types of lung cancer the latter group is more likely to develop lung cancer as a result of a genetic mutation or abnormality. There are also people who are considered never-smokers, who have never smoked or who have smoked fewer than 100 cigarettes in their lifetimes. According to the American Cancer Society, as many as 20 percent of people in the United States who died from lung cancer in 2018-a total of roughly 30,000 people-never smoked.Ī nonsmoker is a person who doesn’t currently smoke, but may have smoked 100 or so cigarettes at some point in their life. And it’s true that the odds of avoiding lung cancer are in your favor-but some nonsmokers get it anyway. If you have never puffed on a cigarette in your life, you may think you won’t get lung cancer. ![]()
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